Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439454 | 0.88 | GAA (0.45) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL6435667 | 0.87 | MAPT (0.42) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL6431994 | 0.82 | GAA (0.46) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL6416313 | 0.79 | MAPT (0.47) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL6432336 | 0.77 | SMN1; SMN2 (0.37) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL26035097 | 0.76 | MAPK1 (0.46) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL26035099 | 0.74 | STK17B (0.48) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL3056423 | 0.74 | TP53 (0.63) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL26035439 | 0.73 | TP53 (0.56) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL6435103 | 0.71 | HTT (0.33) | POLBALDH1A1KDM4EKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |