Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788083 | 1.00 | HPGD (0.60) | HPGDMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL14183971 | 0.87 | KMT2A (0.63) | HPGDMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL4929420 | 0.86 | HPGD (0.53) | HPGDMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3240749 | 0.84 | LMNA (0.55) | HPGDGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4747291 | 0.84 | GAA (0.58) | HPGDMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL15514213 | 0.83 | KMT2A (0.63) | HPGDMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5866871 | 0.83 | ALDH1A1 (0.71) | HPGDMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL27754759 | 0.82 | GAA (0.54) | HPGDMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL14381152 | 0.82 | GAA (0.54) | HPGDMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL6431910 | 0.82 | PLA2G1B (0.57) | HPGDMEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005020895-A2 | METHOD FOR THE TREATMENT OR PREVENTION OF BONE DISORDERS WITH A CYCLOOXYGENASE-2 INHIBITOR ALONE AND IN COMBINATION WITH A BONE DISORDER TREATMENT AGENT AND COMPOSITIONS THEREWITH | PHARMACIA CORPORATION (US) | 2005-03-10 | — | — | WO | disclosed |
| US-5610190-A | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1997-03-11 | — | — | US | disclosed |
| US-5602175-A | HYDROXYETHYLAMINE COMPOUNDS; USEFUL IN TREATMENT OF INFECTIONS CAUSED BY THE HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1997-02-11 | — | — | US | disclosed |
| US-5510487-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |