Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14504414 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2AATMPOLB | |
| SCHEMBL18595261 | 0.77 | ZDHHC7 (0.37) | SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL31631362 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ACYP3A4ATM | |
| SCHEMBL16699711 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2AATMPOLB | |
| SCHEMBL19701698 | 0.74 | ALDH1A1 (0.40) | SMN1; SMN2MEN1KMT2ATSHRCYP3A4 | |
| SCHEMBL3759233 | 0.74 | FAAH (0.42) | CA1KMT2A | |
| SCHEMBL2917903 | 0.73 | FAAH (0.44) | KMT2A | |
| SCHEMBL11383592 | 0.73 | SMN1; SMN2 (0.36) | SMN1; SMN2MEN1KMT2AATMPOLB | |
| SCHEMBL12868735 | 0.71 | ALDH1A1 (0.39) | SMN1; SMN2MEN1KMT2AATMPOLB | |
| SCHEMBL1239842 | 0.71 | GPR84 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313738-A4 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | IMMUNOGEN INC (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-1313738-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | Immunogen, Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002016368-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | IMMUNOGEN, INC. (US) | 2002-02-28 | — | — | WO | disclosed |