Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844675 | 0.83 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5844265 | 0.81 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL11677180 | 0.75 | MEN1 (0.35) | CRHR1CCNA2CDK2TDP1 | |
| SCHEMBL5843803 | 0.72 | CRHR1 (0.38) | CRHR1CCNA2CDK2MAPTTDP1 | |
| SCHEMBL5843388 | 0.70 | CRHR1 (0.48) | ALDH1A1CRHR1 | |
| SCHEMBL11526154 | 0.69 | HCAR3 (0.48) | ALDH1A1LMNASMN1; SMN2MAPTTDP1 | |
| SCHEMBL2282836 | 0.68 | ATM (0.41) | ALDH1A1CRHR1LMNACCNA2CDK2 | |
| SCHEMBL5843954 | 0.67 | CRHR1 (0.41) | ALDH1A1CRHR1LMNASMN1; SMN2MAPT | |
| SCHEMBL7477014 | 0.67 | KEAP1 (0.38) | ALDH1A1CRHR1LMNAMAPTKDM4E | |
| SCHEMBL11678131 | 0.66 | CRHR1 (0.36) | CRHR1LMNACCNA2CDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |