Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.57 |
| ▸ | CCR2 | P41597 | 3/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.54 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.54 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430298 | 0.91 | F10 (0.83) | F10SRD5A2PLA2G10PPARGMRGPRX4 | |
| SCHEMBL6435781 | 0.90 | F10 (0.82) | F10SRD5A2CCR2LTB4RLTB4R2 | |
| SCHEMBL6432399 | 0.89 | F10 (0.84) | F10PPARGF2 | |
| SCHEMBL27497454 | 0.84 | PLA2G10 (0.74) | F10CCR2PLA2G10F2 | |
| SCHEMBL6433052 | 0.83 | F10 (0.63) | F10CCR2PLA2G10F2 | |
| SCHEMBL3967516 | 0.82 | CCR2 (0.73) | F10SRD5A2CCR2LTB4RLTB4R2 | |
| SCHEMBL6432803 | 0.81 | CCR2 (0.70) | F10SRD5A2CCR2LTB4RLTB4R2 | |
| Acetic Acid SCHEMBL7717345 | 0.79 | F10 (0.95) | F10PLA2G2AF2 | |
| Iodide SCHEMBL6432604 | 0.79 | F10 (0.98) | F10F2 | |
| SCHEMBL700511 | 0.78 | SRD5A2 (0.73) | F10SRD5A2CCR2LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |