Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 2/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432910 | 1.00 | ADRB1 (0.32) | ADRB1ADRB3ADRB2CASRPTGDR | |
| SCHEMBL6435354 | 0.94 | GABRA2 (0.35) | FGFR1KDRKDM4EMAPTMAPK1 | |
| SCHEMBL6435353 | 0.94 | GABRA2 (0.35) | FGFR1KDRKDM4EMAPTMAPK1 | |
| SCHEMBL6435848 | 0.83 | ADRB1 (0.45) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6432465 | 0.82 | ADRB3 (0.52) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6432460 | 0.82 | ADRB3 (0.52) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL7974523 | 0.82 | ATR (0.35) | ADRB1ADRB3ADRB2CASRBACE1 | |
| SCHEMBL7974519 | 0.82 | ATR (0.35) | ADRB1ADRB3ADRB2CASRBACE1 | |
| SCHEMBL6435843 | 0.82 | ADRB1 (0.43) | ADRB1ADRB3ADRB2CASR | |
| SCHEMBL6438415 | 0.81 | ADRB2 (0.45) | ADRB1ADRB3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1087943-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065877-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |