Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 12/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 12/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 11/20 | 0.42 |
| ▸ | RORB | Q92753 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964117 | 0.87 | ADRB1 (0.46) | ADRB1ADRB3ADRB2 | |
| SCHEMBL5950125 | 0.87 | ADRB1 (0.44) | ADRB1ADRB3ADRB2 | |
| SCHEMBL5949915 | 0.87 | ADRB1 (0.43) | ADRB1ADRB3ADRB2SMN1; SMN2 | |
| SCHEMBL6433079 | 0.86 | ADRB3 (0.48) | ADRB1ADRB3ADRB2RORB | |
| SCHEMBL6433080 | 0.86 | ADRB3 (0.48) | ADRB1ADRB3ADRB2RORB | |
| SCHEMBL7975458 | 0.85 | ADRB2 (0.44) | ADRB1ADRB3ADRB2 | |
| SCHEMBL6436830 | 0.85 | ADRB1 (0.42) | ADRB1ADRB3ADRB2BACE1 | |
| SCHEMBL6436894 | 0.85 | ADRB1 (0.44) | ADRB1ADRB3ADRB2 | |
| SCHEMBL7963988 | 0.84 | MAPT (0.37) | ADRB1ADRB3ADRB2BACE1SMN1; SMN2 | |
| SCHEMBL6432465 | 0.83 | ADRB3 (0.52) | ADRB1ADRB3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1087943-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065877-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |