Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.33 |
| ▸ | MICA | Q29983 | 1/20 | 0.33 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975406 | 0.96 | MAPT (0.38) | MAPTNPSR1KDM4EMAPK1ADRB1 | |
| SCHEMBL7975401 | 0.96 | MAPT (0.38) | MAPTNPSR1KDM4EMAPK1ADRB1 | |
| SCHEMBL7963984 | 0.86 | ADRB1 (0.39) | MAPTNPSR1KDM4EMAPK1ADRB1 | |
| SCHEMBL7963987 | 0.86 | ADRB1 (0.39) | MAPTNPSR1KDM4EMAPK1ADRB1 | |
| SCHEMBL6433084 | 0.84 | ADRB1 (0.42) | ADRB1ADRB3ADRB2SMN1; SMN2BACE1 | |
| SCHEMBL7964117 | 0.82 | ADRB1 (0.46) | ADRB1ADRB3ADRB2KLRK1MICA | |
| SCHEMBL7975458 | 0.80 | ADRB2 (0.44) | ADRB1ADRB3ADRB2 | |
| SCHEMBL5949915 | 0.79 | ADRB1 (0.43) | MAPTNPSR1KDM4EMAPK1ADRB1 | |
| SCHEMBL5950125 | 0.79 | ADRB1 (0.44) | ADRB1ADRB3ADRB2 | |
| SCHEMBL6436894 | 0.79 | ADRB1 (0.44) | ADRB1ADRB3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001042217-A1 | BETA-3 ADRENOCEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2001-06-14 | — | — | WO | disclosed |