Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 8/20 | 0.41 |
| ▸ | THRB | P10828 | 8/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium SCHEMBL6433640 | 0.98 | MTNR1A (0.47) | MTNR1AGAATHRATHRBEGLN1 | |
| SCHEMBL6432839 | 0.89 | MTNR1A (0.50) | MTNR1ANQO2KMT2AMEN1 | |
| Lithium Ion SCHEMBL6433635 | 0.88 | MTNR1A (0.46) | MTNR1ANQO2KMT2AMEN1 | |
| SCHEMBL6410573 | 0.82 | MTNR1A (0.47) | MTNR1ANQO2 | |
| SCHEMBL6432988 | 0.80 | NQO2 (0.47) | MTNR1AGAAHIF1ANQO2 | |
| SCHEMBL6582651 | 0.76 | MTNR1A (0.52) | MTNR1ANQO2 | |
| SCHEMBL2230132 | 0.72 | HDAC8 (0.61) | FTOKEAP1 | |
| SCHEMBL6583218 | 0.69 | HTR2A (0.49) | MTNR1ANQO2 | |
| SCHEMBL6417161 | 0.69 | HTR2A (0.35) | MTNR1ANQO2 | |
| SCHEMBL7714927 | 0.67 | TRPV1 (0.43) | GAANQO2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090011-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6410534-B1 | ANTICANCER AGENTS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |
| EP-1090011-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001701-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |