SCHEMBL6433934

SCHEMBL6433934

CO[Si](OC)(OC)c1ccccc1C=Cc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 8/20 0.55
TRPA1 O75762 3/20 0.55
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44
TUBA1A Q71U36 1/20 0.44
TUBA1C Q9BQE3 1/20 0.44
TUBB6 Q9BUF5 1/20 0.44
TUBB2B Q9BVA1 1/20 0.44
TUBB1 Q9H4B7 1/20 0.44
CYP1A1 P04798 2/20 0.44
CYP1A2 P05177 2/20 0.44
CYP1B1 Q16678 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20482327 1.00 NFE2L2 (0.55) NFE2L2TRPA1TUBB4ATUBBTUBA3C
SCHEMBL20584028 0.90 NFE2L2 (0.39) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL20584026 0.90 NFE2L2 (0.39) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL7188756 0.84 NFE2L2 (0.53) NFE2L2TRPA1TUBB4ATUBBTUBA3C
SCHEMBL27801222 0.81 CYP3A4 (0.35) NFE2L2TRPA1CYP1A1CYP1A2CYP1B1
SCHEMBL25878850 0.79 NFE2L2 (0.50) NFE2L2TRPA1RELAKDM4EATP4A
SCHEMBL6882972 0.78 NFE2L2 (0.54) NFE2L2TRPA1KDM4EATP4AATP4B
SCHEMBL6882976 0.78 NFE2L2 (0.54) NFE2L2TRPA1KDM4EATP4AATP4B
SCHEMBL7187435 0.76 TRPA1 (0.52) NFE2L2TRPA1RELAKDM4EATP4A
SCHEMBL7188391 0.75 NFE2L2 (0.47) NFE2L2TRPA1TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200056994-A1 FLUORESCENT SILANE LAYERS FOR DETECTING EXPLOSIVES INSTITUT DR. FOERSTER GMBH & CO. KG (DE) 2020-02-20 US claimed
US-20200056994-A1 FLUORESCENT SILANE LAYERS FOR DETECTING EXPLOSIVES INSTITUT DR. FOERSTER GMBH & CO. KG (DE) 2020-02-20 US disclosed
EP-1276807-B1 CURABLE SILICONE RESIN COMPOSITION AND REACTIVE SILICON COMPOUNDS DOW CORNING (US) 2005-10-12 EP disclosed
EP-1276807-A1 CURABLE SILICONE RESIN COMPOSITION AND REACTIVE SILICON COMPOUNDS Dow Corning Corporation (US) 2003-01-22 EP disclosed
WO-2001083608-A1 CURABLE SILICONE RESIN COMPOSITION AND REACTIVE SILICON COMPOUNDS DOW CORNING CORPORATION (US) 2001-11-08 WO disclosed