Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL6434973

O=C(O)C(F)(F)F.O=C1NC(=O)c2cnccc21

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.39
SLC22A12 Q96S37 11/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
CDC25B P30305 1/20 0.37
TSHR P16473 2/20 0.37
ALDH1A1 P00352 1/20 0.37
GSK3B P49841 2/20 0.36
CDC7 O00311 1/20 0.36
ROCK2 O75116 1/20 0.36
MAP4K4 O95819 1/20 0.36
PRKACA P17612 1/20 0.36
CDK2 P24941 1/20 0.36
HIPK2 Q9H2X6 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36
IRAK4 Q9NWZ3 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
TP53 P04637 1/20 0.34
CYP3A4 P08684 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31318 0.84 GSK3B (0.50) NPSR1MAOAMAOBCDC25BTSHR
Phthalimide SCHEMBL25328900 0.78 GSK3B (0.62) NPSR1MAOAMAOBALDH1A1GSK3B
Phthalimide SCHEMBL30718274 0.78 GSK3B (0.62) NPSR1MAOAMAOBALDH1A1GSK3B
Phthalimide SCHEMBL29391542 0.78 GSK3B (0.62) NPSR1MAOAMAOBALDH1A1GSK3B
Trifluoroacetic Acid SCHEMBL30343227 0.71 L3MBTL1 (0.42) SLC22A12ALDH1A1GSK3BCDC7MAP4K4
Trifluoroacetic Acid SCHEMBL22980504 0.68 KDM1A (0.34) HRH4HRH3
Trifluoroacetic Acid SCHEMBL5015284 0.68 TDP1 (0.56) SLC22A12ALDH1A1CDC7L3MBTL1MAPT
Isoquinoline SCHEMBL4339110 0.67 IMPDH2 (0.46) SLC22A12ROCK2L3MBTL1CYP3A4
Trifluoroacetic Acid SCHEMBL30967251 0.67 HRH4 (0.43) TSHRALDH1A1L3MBTL1TP53CYP3A4
Isoquinoline SCHEMBL4339108 0.67 IMPDH2 (0.46) SLC22A12ROCK2L3MBTL1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1458723-A4 FUSED HETEROCYCLIC SUCCINIMIDECOMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION BRISTOL MYERS SQUIBB CO (US) 2005-12-21 EP disclosed
EP-1458723-A1 FUSED HETEROCYCLIC SUCCINIMIDECOMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION Bristols-Myers Squibb Company (US) 2004-09-22 EP disclosed
WO-2003062241-A1 FUSED HETEROCYCLIC SUCCINIMIDECOMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2003-07-31 WO disclosed