Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13426 | 0.77 | LMNA (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL22257228 | 0.73 | ALDH1A1 (0.44) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL1279 | 0.73 | CYP1A2 (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL1683 | 0.72 | CYP1A2 (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL6483 | 0.72 | CYP1A2 (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL3829 | 0.72 | P2RX7 (0.42) | RAB9ASMN1; SMN2NPC1TP53CYP1A2 | |
| SCHEMBL6329 | 0.72 | CYP1A2 (0.36) | RAB9ASMN1; SMN2NPC1ALDH1A1CYP1A2 | |
| SCHEMBL1185 | 0.71 | CYP1A2 (0.44) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL18597812 | 0.71 | CYP1A2 (0.44) | RAB9ASMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL24042873 | 0.71 | ALDH1A1 (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |