Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29936164 | 0.90 | HDAC3 (0.41) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL27245174 | 0.82 | ALDH1A1 (0.52) | NPC1RAB9AHPGDPOLBALDH1A1 | |
| SCHEMBL5027223 | 0.81 | PDK1 (0.41) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL23455657 | 0.80 | ALDH1A1 (0.50) | PDK1PDK2PDK3PDK4GABRA1 | |
| SCHEMBL11035298 | 0.79 | ANO1 (0.47) | NPC1RAB9AHPGDPOLBALDH1A1 | |
| SCHEMBL11566692 | 0.78 | SSTR4 (0.52) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL3650057 | 0.78 | KCNN4 (0.42) | GABRA1GABRB2NPC1RAB9AHPGD | |
| SCHEMBL11303236 | 0.78 | CYP3A4 (0.52) | PDK1PDK2PDK3PDK4GABRA1 | |
| SCHEMBL935057 | 0.77 | SSTR4 (0.53) | KDM4EGAAHDAC3HDAC4HDAC1 | |
| SCHEMBL5057355 | 0.77 | GABRA1 (0.43) | PDK1PDK2PDK3PDK4GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050049282-A1 | Process | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | US | claimed |
| EP-1458709-A1 | NEW PROCESS | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051867-A1 | NEW PROCESS | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049282-A1 | Process | CYP3A5, CYP3A4, PGA5 | PDK1 1248/4885PDK2 1169/4885PDK3 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.