Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.50 |
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180426 | 0.96 | — | — | |
| SCHEMBL15271850 | 0.92 | CES2 (0.50) | CES2CES1BCHEACHENFE2L2 | |
| Bromide SCHEMBL8429963 | 0.89 | CES2 (0.48) | CES2CES1BCHEACHENFE2L2 | |
| SCHEMBL59882 | 0.83 | CES2 (0.50) | CES2CES1BCHEACHENFE2L2 | |
| Boric Acid SCHEMBL28374876 | 0.83 | CES2 (0.50) | CES2CES1BCHEACHENFE2L2 | |
| SCHEMBL330689 | 0.81 | — | — | |
| SCHEMBL3038641 | 0.79 | CES2 (0.46) | CES2CES1BCHE | |
| SCHEMBL3545494 | 0.78 | CES2 (0.46) | CES2CES1BCHEACHESLC6A2 | |
| Pyrrole SCHEMBL28534029 | 0.78 | CES2 (0.41) | CES2CES1BCHEACHESLC6A2 | |
| Thiourea SCHEMBL6832788 | 0.78 | CES2 (0.46) | CES2CES1BCHEHPGDHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6870067-B2 | Process for the synthesis of trifluorophenylacetic acids | MERCK & CO., INC. (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | MERCK SHARP & DOHME LLC | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | GRHPR, PFAS, PCCA | CES2 1431/4885CES1 2759/4885BCHE 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.