Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439454 | 0.84 | GAA (0.45) | SMN1; SMN2TP53MAPTCDKN1ALMNA | |
| SCHEMBL6416039 | 0.80 | MEN1 (0.44) | SMN1; SMN2TP53MAPTCDKN1ARXFP1 | |
| SCHEMBL6431994 | 0.78 | GAA (0.46) | SMN1; SMN2TP53MAPTCDKN1ALMNA | |
| SCHEMBL6436802 | 0.77 | MAPT (0.44) | SMN1; SMN2TP53MAPTCDKN1APOLB | |
| SCHEMBL6435667 | 0.76 | MAPT (0.42) | SMN1; SMN2TP53MAPTCDKN1ALMNA | |
| SCHEMBL8191790 | 0.72 | LMNA (0.45) | RXFP1METAP1LMNAPOLBGAA | |
| SCHEMBL6435103 | 0.72 | HTT (0.33) | LMNAPOLBKMT2AALDH1A1HTT | |
| SCHEMBL6435528 | 0.70 | HTT (0.32) | HTT | |
| SCHEMBL2880191 | 0.69 | LMNA (0.54) | SMN1; SMN2RXFP1METAP1LMNAPOLB | |
| SCHEMBL13300748 | 0.66 | STK17B (0.54) | P2RX7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |