Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 4/20 | 0.56 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11871225 | 0.87 | VCAM1 (0.65) | VCAM1XDHALDH1A1TSHRGPR35 | |
| SCHEMBL14162639 | 0.86 | VCAM1 (0.55) | VCAM1XDHALDH1A1TDP1TSHR | |
| SCHEMBL6431969 | 0.82 | ALDH1A1 (0.64) | VCAM1XDHALDH1A1TSHRGPR35 | |
| SCHEMBL768569 | 0.81 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRGPR35LMNA | |
| SCHEMBL4665872 | 0.81 | VCAM1 (0.58) | VCAM1XDHALDH1A1TDP1GPR35 | |
| SCHEMBL11939746 | 0.80 | VCAM1 (0.61) | VCAM1XDHALDH1A1TDP1TSHR | |
| SCHEMBL6431811 | 0.79 | ALDH1A1 (0.59) | VCAM1XDHALDH1A1TDP1TSHR | |
| SCHEMBL2967615 | 0.79 | XDH (0.66) | VCAM1XDHALDH1A1TDP1TSHR | |
| SCHEMBL16237206 | 0.79 | VCAM1 (0.52) | VCAM1XDHALDH1A1TDP1TSHR | |
| SCHEMBL20299265 | 0.79 | VCAM1 (0.52) | VCAM1XDHALDH1A1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033364-B1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6194454-B1 | ANTILIPEMIC AGENTS; ANTIDIABETIC AGENTS; DIETETICS; RHEUMATIC DISEASES; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTIDEPRESSANTS; BONE DISORDERS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1033364-A1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |