Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.50 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669236 | 0.88 | GCK (0.49) | GCKEZH2 | |
| SCHEMBL644377 | 0.85 | GCK (0.52) | GCKEZH2LPAR1LPAR5FFAR4 | |
| SCHEMBL643703 | 0.83 | GCK (0.53) | GCKEZH2LPAR1LPAR5FFAR4 | |
| SCHEMBL9923403 | 0.82 | GCK (0.49) | GCKEZH2SCN9A | |
| SCHEMBL2669358 | 0.80 | GCK (0.46) | GCK | |
| SCHEMBL642567 | 0.79 | GCK (0.59) | GCK | |
| SCHEMBL643673 | 0.79 | GCK (0.59) | GCK | |
| SCHEMBL643823 | 0.79 | GCK (0.78) | GCK | |
| SCHEMBL643599 | 0.79 | GCK (0.65) | GCK | |
| SCHEMBL643421 | 0.79 | GCK (0.56) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |