SCHEMBL6437413

SCHEMBL6437413

Fc1c(F)c(F)c(Oc2c(F)c(F)c(F)c(F)c2Cl)c(F)c1F

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.34
KDM4E B2RXH2 1/20 0.34
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34
POLB P06746 1/20 0.31
HSP90AA1 P07900 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11227564 0.91 KDM4E (0.31) MAPTKDM4ECRHBPCRHR2
SCHEMBL2001423 0.80 CA1 (0.38) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL1157893 0.80 CA1 (0.38) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL6439378 0.79
SCHEMBL30361446 0.77 CA1 (0.36) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL4594249 0.71 CES2 (0.36) KDM4E
SCHEMBL5404508 0.71 MAPT (0.39) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL7875124 0.71 MAPT (0.39) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL30688717 0.71 MAPT (0.39) MAPTKDM4ECRHBPCRHR2POLB
SCHEMBL4805284 0.71 MAPT (0.39) MAPTKDM4ECRHBPCRHR2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1009729-B1 HALOGENATED ACRYLATES AND POLYMERS DERIVED THEREFROM MINNESOTA MINING & MFG (US) 2005-01-19 EP disclosed
US-6362379-B2 ACRYLATES HAVING HIGH DEGREE OF HALOGENATION AND POLYMERS USING THESE MONOMERS; USEFUL FOR OPTICAL WAVEGUIDES AND TELECOMMUNICATION 3M INNOVATIVE PROPERTIES COMPANY 2002-03-26 US disclosed
US-6313245-B1 USED IN OPTICAL DEVICES INCLUDING OPTICAL WAVEGUIDES AND INTERCONNECTING DEVICES 3M INNOVATIVE PROPERTIES COMPANY 2001-11-06 US disclosed
US-20010037028-A1 Halogenated acrylates and polymers derived therefrom 3M INNOVATIVE PROPERTIES COMPANY 2001-11-01 US disclosed
US-6288266-B1 HALOGENATED ACRYLATES OR THIOACRYLATES FOR POLYMERS 3M INNOVATIVE PROPERTIES COMPANY 2001-09-11 US disclosed
EP-1009729-A1 HALOGENATED ACRYLATES AND POLYMERS DERIVED THEREFROM MINNESOTA MINING AND MANUFACTURING COMPANY (US) 2000-06-21 EP disclosed
US-6005137-A POLYMERS USED IN OPTICAL DEVICES INCLUDING OPTICAL WAVEGUIDES AND INTERCONNECTING DEVICES 3M INNOVATIVE PROPERTIES COMPANY (US) 1999-12-21 US disclosed
WO-1998056749-A1 HALOGENATED ACRYLATES AND POLYMERS DERIVED THEREFROM MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-12-17 WO disclosed
EP-0024019-B1 PROCESS FOR THE PRODUCTION OF 4-FLUORO-3-PHENOXY-TOLUENE BAYER AG (DE) 1982-08-11 EP disclosed
US-4316994-A Preparation of 4-fluoro-3-phenoxy-toluene BAYER AKTIENGESELLSCHAFT (DE) 1982-02-23 US disclosed
EP-0008734-B1 PROCESS FOR THE PREPARATION OF 4-FLUOR-3-PHENOXYTOLUENE BAYER AG (DE) 1981-07-29 EP disclosed
US-4266082-A Preparation of 4-fluoro-3-phenoxy-toluene BAYER AKTIENGESELLSCHAFT (DE) 1981-05-05 US disclosed
EP-0024019-A1 Process for the production of 4-fluoro-3-phenoxy-toluene BAYER AG (DE) 1981-02-18 EP disclosed
EP-0017882-A1 Process for the preparation of 3-phenoxy-4-fluoro-benzoic acid BAYER AG (DE) 1980-10-29 EP disclosed
EP-0008734-A1 Process for the preparation of 4-fluor-3-phenoxytoluene BAYER AG (DE) 1980-03-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010037028-A1 Halogenated acrylates and polymers derived therefrom ZYX, ACR, ORMDL3 MAPT 694/4885KDM4E 4428/4885CRHBP 3414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.