Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RNF4 | P78317 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246777 | 0.78 | TSPO (0.49) | RAB9ANPC1MITFKMT2AALDH1A1 | |
| SCHEMBL15670616 | 0.78 | KMT2A (0.49) | RAB9ANPC1MITFKMT2AALDH1A1 | |
| SCHEMBL13035846 | 0.74 | POLB (0.50) | RAB9ANPC1KMT2AALDH1A1MEN1 | |
| SCHEMBL23144578 | 0.73 | MEN1 (0.47) | RAB9ANPC1MITFKMT2AALDH1A1 | |
| SCHEMBL3625774 | 0.72 | TSPO (0.43) | RAB9ANPC1KMT2AALDH1A1MEN1 | |
| SCHEMBL11033445 | 0.72 | MTNR1A (0.53) | RAB9ANPC1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL10903904 | 0.72 | ALDH1A1 (0.44) | KMT2AALDH1A1MEN1HTTSMN1; SMN2 | |
| SCHEMBL15366455 | 0.71 | ALDH1A1 (0.47) | MITFKMT2AALDH1A1MEN1HTT | |
| SCHEMBL31186740 | 0.71 | ALDH1A1 (0.55) | RAB9ANPC1KMT2AALDH1A1MEN1 | |
| SCHEMBL9133855 | 0.70 | MTNR1A (0.51) | RAB9ANPC1ALDH1A1HTTRNF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090011-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6410534-B1 | ANTICANCER AGENTS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |
| EP-1090011-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001701-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |