Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GGT1 | P19440 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10825614 | 0.89 | HTR2A (0.51) | HTTALDH1A1KDM4EPOLBHTR2A | |
| SCHEMBL28940516 | 0.86 | KDM4E (0.51) | HTTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL10897162 | 0.86 | ALDH1A1 (0.51) | HTTALDH1A1POLBHTR2ASLC6A4 | |
| SCHEMBL8337734 | 0.84 | HTT (0.48) | HTTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL28940646 | 0.84 | HTT (0.48) | HTTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL25815354 | 0.83 | KDM4E (0.50) | ALDH1A1KDM4EPOLBHTR2ASLC6A4 | |
| SCHEMBL28940652 | 0.83 | HTT (0.53) | HTTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL28411450 | 0.82 | CTNNB1 (0.66) | HTTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL28634306 | 0.81 | POLB (0.61) | HTTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL30775034 | 0.81 | HTT (0.59) | HTTALDH1A1KDM4EPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050054882-A1 | Diaryl ether condensation reactions | NSF - DEITR | 2005-03-10 | — | — | US | disclosed |
| US-6762329-B2 | EFFECTS OF ACIDIC ACTIVATORS ON ULLMANN-TYPE COUPLINGS INVOLVING ELECTRON-POOR AND/OR RELATIVELY INSOLUBLE SUBSTRATES. | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2004-07-13 | — | — | US | disclosed |
| US-20030088128-A1 | Diaryl ether condensation reactions | NATIONAL SCIENCE FOUNDATION | 2003-05-08 | — | — | US | disclosed |
| US-6395939-B1 | CATALYTIC ETHERIFICATION AND CONDENSATION WITH COPPER CATALYSTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-05-28 | — | — | US | disclosed |
| WO-1999018057-A1 | PREPARATION OF DIARYL ETHER BY CONDENSATION REACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-04-15 | — | — | WO | disclosed |
| US-5770614-A | EXCELLENT ACTIVITY OF CONTROLLING PSEUDOCERCOSPORELLA HERPOTRICHOIDES | SHIONOGI & CO., LTD. (JP) | 1998-06-23 | — | — | US | disclosed |
| EP-0760363-A1 | 2-(SUBSTITUTED PHENYL)-2-ALKOXYIMINO-N-ALKYLACETAMIDE COMPOUND AND BACTERICIDE CONTAINING THE SAME | SHIONOGI & CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054882-A1 | Diaryl ether condensation reactions | NSFL1C, DERL1, UBE2M | HTT 3396/4885ALDH1A1 1863/4885KDM4E 1568/4885 |
| US-20030088128-A1 | Diaryl ether condensation reactions | NSFL1C, DERL1, UBE2M | HTT 3396/4885ALDH1A1 1863/4885KDM4E 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.