Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438571 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1HPGDGAASCN9A | |
| SCHEMBL3368548 | 0.79 | PPARG (0.46) | KDM4EALDH1A1HPGDGAAFFAR1 | |
| SCHEMBL3372499 | 0.77 | PPARG (0.39) | KDM4EALDH1A1HPGDGAAFFAR1 | |
| SCHEMBL13140171 | 0.73 | PPARA (0.52) | KDM4EALDH1A1HPGDFFAR1PPARA | |
| SCHEMBL3372557 | 0.73 | LMNA (0.68) | KDM4EALDH1A1HPGDGAANPC1 | |
| SCHEMBL13140345 | 0.72 | ALOX5 (0.56) | KDM4EALDH1A1HPGDFFAR1SCN9A | |
| SCHEMBL27611558 | 0.72 | RAB9A (0.49) | KDM4EALDH1A1HPGDGAANPC1 | |
| SCHEMBL14495980 | 0.71 | KDM4E (0.62) | KDM4EALDH1A1HPGDGAAFFAR1 | |
| SCHEMBL3370374 | 0.71 | PPARA (0.43) | KDM4EALDH1A1HPGDGAAFFAR1 | |
| SCHEMBL13140344 | 0.71 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDFFAR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537091-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004020420-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-03-11 | — | — | WO | disclosed |