SCHEMBL6439100

SCHEMBL6439100

COc1c(Cl)c(Cl)c(CO)c(Cl)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.46
CA4 P22748 2/20 0.46
IMPDH2 P12268 2/20 0.33
MAPT P10636 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
PDE5A O76074 1/20 0.30
PDE4A P27815 1/20 0.30
PDE1A P54750 1/20 0.30
PDE1B Q01064 1/20 0.30
PDE4B Q07343 1/20 0.30
PDE4C Q08493 1/20 0.30
PDE4D Q08499 1/20 0.30
PDE3B Q13370 1/20 0.30
PDE1C Q14123 1/20 0.30
PDE3A Q14432 1/20 0.30
CA1 P00915 1/20 0.30
CA6 P23280 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL522497 0.78 PDXK (0.33)
SCHEMBL13880635 0.78 KDM4E (0.35) CA2MAPTKDM4EALDH1A1GAA
SCHEMBL6442145 0.75 GCGR (0.33) CA2CA4
SCHEMBL301807 0.74 CA1 (0.35) CA2KDM4EALDH1A1GAACA1
SCHEMBL306109 0.74 MEN1 (0.35) MAPTALDH1A1
SCHEMBL6828106 0.73 CA2 (0.50) CA2CA4IMPDH2CA1CA6
SCHEMBL9108639 0.73 CA2 (0.54) CA2CA4MAPTPDE5APDE4A
SCHEMBL27929758 0.72 CA1 (0.33) CA2KDM4EALDH1A1GAACA1
SCHEMBL560496 0.72 MEN1 (0.33) MAPTALDH1A1
SCHEMBL21280364 0.71 PDE4A (0.43) CA2CA4MAPTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1203760-B1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL CO (JP) 2005-04-13 EP disclosed
US-6706910-B2 BY TRANSESTERIFICATION OF A CYCLOPROPANECARBOXYLATE AND A MONOHYDROXY COMPOUND IN THE PRESENCE OF A LITHIUM ALKOXIDE OR LITHIUM ARYLOXIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-03-16 US disclosed
EP-1203760-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-08 EP disclosed
US-20020052525-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020052525-A1 Method for producing cyclopropanecarboxylates CYP8B1, SRD5A2, CYP21A2 CA2 650/4885CA4 262/4885IMPDH2 1015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.