SCHEMBL6442145

SCHEMBL6442145

COCc1c(Cl)c(Cl)c(CO)c(Cl)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.33
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
IGF1R P08069 1/20 0.31
SRC P12931 1/20 0.31
AXL P30530 1/20 0.31
PTK2 Q05397 1/20 0.31
AURKB Q96GD4 1/20 0.31
ALK Q9UM73 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11235652 0.87 KDM4E (0.33) IGF1RSRCAXLPTK2AURKB
SCHEMBL522497 0.78 PDXK (0.33)
SCHEMBL19478240 0.76 GCGR (0.35) GCGR
SCHEMBL6439100 0.75 CA2 (0.46) CA2CA4
SCHEMBL306109 0.74 MEN1 (0.35)
SCHEMBL560496 0.72 MEN1 (0.33)
SCHEMBL6439849 0.70
SCHEMBL359266 0.70 GCGR (0.39) GCGRCA2CA4IGF1RSRC
SCHEMBL11318159 0.68 MEN1 (0.35)
SCHEMBL9812427 0.67 TSHR (0.53)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1203760-B1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL CO (JP) 2005-04-13 EP disclosed
US-6706910-B2 BY TRANSESTERIFICATION OF A CYCLOPROPANECARBOXYLATE AND A MONOHYDROXY COMPOUND IN THE PRESENCE OF A LITHIUM ALKOXIDE OR LITHIUM ARYLOXIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-03-16 US disclosed
EP-1203760-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-08 EP disclosed
US-20020052525-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020052525-A1 Method for producing cyclopropanecarboxylates CYP8B1, SRD5A2, CYP21A2 GCGR 2994/4885CA2 650/4885CA4 262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.