Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | PPIA | P62937 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444776 | 0.89 | KEAP1 (0.41) | LMNAMAPK14DHODHKDM4CPPARG | |
| SCHEMBL5745770 | 0.83 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2HTT | |
| SCHEMBL27527595 | 0.83 | KDM4C (0.35) | LMNAMAPK14ERN1MRGPRX4PTGER1 | |
| SCHEMBL27527592 | 0.78 | MRGPRX4 (0.37) | LMNADHODHMRGPRX4PTGER1KDM4C | |
| SCHEMBL7253009 | 0.77 | MEN1 (0.41) | LMNAMAPK14SMN1; SMN2HTTNPC1 | |
| SCHEMBL6443197 | 0.77 | CNR1 (0.43) | SMN1; SMN2HTT | |
| SCHEMBL1554049 | 0.75 | ALDH1A1 (0.42) | LMNAMAPK14SMN1; SMN2HTTNPC1 | |
| SCHEMBL6440225 | 0.74 | DYRK1A (0.36) | LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL6025036 | 0.73 | GAA (0.38) | LMNASMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL6443205 | 0.73 | MAPK9 (0.34) | LMNAHTTNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499577-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | disclosed |