Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440239 | 0.89 | LMNA (0.34) | STAT3HTTSMN1; SMN2LMNADHODH | |
| SCHEMBL5745770 | 0.84 | SMN1; SMN2 (0.45) | HTTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL7253009 | 0.78 | MEN1 (0.41) | HTTSMN1; SMN2LMNAMAPK9MAPK10 | |
| SCHEMBL6443197 | 0.75 | CNR1 (0.43) | HTTSMN1; SMN2MEN1KMT2ARXRA | |
| SCHEMBL6440316 | 0.75 | SMPD1 (0.41) | SMN1; SMN2RAB9AKMT2AACHE | |
| SCHEMBL6440225 | 0.75 | DYRK1A (0.36) | HTTLMNAMAPK1L3MBTL1ACHE | |
| SCHEMBL6443205 | 0.74 | MAPK9 (0.34) | HTTLMNAMAPK9MAPK10SRC | |
| SCHEMBL5746437 | 0.72 | TLR4 (0.41) | SMN1; SMN2DHODHMEN1KMT2AMAPT | |
| SCHEMBL27527595 | 0.72 | KDM4C (0.35) | STAT3HTTSMN1; SMN2LMNAKDM4C | |
| SCHEMBL6025036 | 0.72 | GAA (0.38) | HTTSMN1; SMN2LMNAMAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499577-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | disclosed |