Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL3569024 | 0.92 | MEN1 (0.38) | PRKCQMEN1KMT2ARIPK2CSNK2A1 | |
| Pyridine SCHEMBL3571503 | 0.75 | CTSK (0.43) | CDK2CDK1CCNB1JAK2JAK1 | |
| SCHEMBL24701363 | 0.73 | ACACB (0.43) | MEN1KMT2AGSK3BCDK2CDC7 | |
| SCHEMBL23169266 | 0.72 | VNN1 (0.47) | PRKCQCSNK2A1ACACBKDM1AAOC1 | |
| SCHEMBL3569022 | 0.70 | GPR39 (0.41) | PRKCQMEN1KMT2ARIPK2CSNK2A1 | |
| SCHEMBL8303007 | 0.69 | PRKCQ (0.34) | PRKCQMEN1KMT2ARIPK2CSNK2A1 | |
| SCHEMBL13403220 | 0.68 | CDC7 (0.51) | MEN1KMT2AGSK3BCDK2CDC7 | |
| SCHEMBL23169314 | 0.68 | ASPH (0.42) | PRKCQMEN1KMT2AGSK3BCDK2 | |
| SCHEMBL25786503 | 0.67 | MAPT (0.34) | MEN1KMT2AJAK2JAK1JAK3 | |
| SCHEMBL23169614 | 0.67 | GPR39 (0.43) | PRKCQMEN1KMT2ACSNK2A1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527070-A1 | AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2005-05-04 | — | — | EP | disclosed |
| WO-2003106455-A1 | AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-12-24 | — | — | WO | disclosed |