SCHEMBL6443530

SCHEMBL6443530

CC(CC(=O)O)c1ccccc1F

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EEF2K O00418 3/20 0.50
FFAR1 O14842 2/20 0.47
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
CNR2 P34972 1/20 0.45
HIF1A Q16665 1/20 0.43
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
CTSA P10619 4/20 0.43
CYP3A4 P08684 1/20 0.43
GAA P10253 1/20 0.42
CPA1 P15085 2/20 0.42
CPB1 P15086 1/20 0.42
CPA3 P15088 1/20 0.42
CPB2 Q96IY4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5685248 0.82 EEF2K (0.50) EEF2KFFAR1MEN1KMT2ACNR2
SCHEMBL27728236 0.82 CPA3 (0.45) EEF2KMEN1KMT2ACNR2HIF1A
SCHEMBL31581805 0.82 EEF2K (0.39) EEF2KFFAR1MEN1KMT2ACTSA
SCHEMBL26455960 0.81 MEN1 (0.48) EEF2KMEN1KMT2ACNR2HIF1A
SCHEMBL8770868 0.79 CES2 (0.49) EEF2KFFAR1MEN1KMT2ACNR2
SCHEMBL559436 0.79 TSHR (0.62) FFAR1CPA1CPB1CPA3CPB2
SCHEMBL6841260 0.79 FFAR1 (0.49) FFAR1CTSA
SCHEMBL1645769 0.78 FFAR1 (0.47) FFAR1CPA1CPB1CPA3CPB2
SCHEMBL2457680 0.78 EEF2K (0.47) EEF2KMEN1KMT2ACNR2CES2
SCHEMBL1646855 0.78 FFAR1 (0.47) FFAR1CPA1CPB1CPA3CPB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107531615-A Indenyl compound, pharmaceutical composition and medical application thereof ADT制药有限责任公司 2018-01-02 CN disclosed
CN-107466232-A The method for treating or preventing the disease of RAS mediations ADT制药有限责任公司 2017-12-12 CN disclosed
EP-3233794-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF ADT Pharmaceuticals, Inc. (US) 2017-10-25 EP disclosed
EP-3233071-A1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES ADT Pharmaceuticals, Inc. (US) 2017-10-25 EP disclosed
EP-2341140-B1 Enzymatic encoding methods for efficient synthesis of large libraries NUEVOLUTION AS (DK) 2017-07-19 EP disclosed
WO-2016100546-A1 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES ADT PHARMACEUTICALS, INC. (US) 2016-06-23 WO disclosed
WO-2016100542-A1 INDENYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF ADT PHARMACEUTICALS, INC. (US) 2016-06-23 WO disclosed
EP-1021402-B1 AROMATIC C16-C20-SUBSTITUTED TETRAHYDRO PROSTAGLANDINS USEFUL AS FP AGONISTS UNIV DUKE (US) 2005-11-23 EP disclosed
WO-2005068411-A1 PROCESS FOR THE PREPARATION OF 6-FLUORO-2-METHYL-1-INDANONE ZAMBON GROUP S.P.A. (IT) 2005-07-28 WO disclosed
EP-1146866-A4 A METHOD FOR TREATING PATIENTS WITH ACNE BY ADMINISTERING A CYCLIC GMP PDE INHIBITOR OSI PHARM INC (US) 2004-12-08 EP disclosed
EP-1146866-A1 A METHOD FOR TREATING PATIENTS WITH ACNE BY ADMINISTERING A CYCLIC GMP PDE INHIBITOR OSI Pharmaceuticals, Inc. (US) 2001-10-24 EP disclosed
EP-1082299-A1 C11 OXYMYL AND HYDROXYLAMINO PROSTAGLANDINS USEFUL AS MEDICAMENTS THE PROCTER & GAMBLE COMPANY (US) 2001-03-14 EP disclosed
US-6107338-A BONE DISORDERS; GLAUCOMA THE PROCTER & GAMBLE COMPANY (US) 2000-08-22 US disclosed
WO-2000044372-A1 A METHOD FOR TREATING PATIENTS WITH ACNE BY ADMINISTERING A CYCLIC GMP PDE INHIBITOR CELL PATHWAYS, INC. (US) 2000-08-03 WO disclosed
EP-1021402-A1 AROMATIC C16-C20-SUBSTITUTED TETRAHYDRO PROSTAGLANDINS USEFUL AS FP AGONISTS THE PROCTER & GAMBLE COMPANY (US) 2000-07-26 EP disclosed
WO-1999050241-A1 C11 OXYMYL AND HYDROXYLAMINO PROSTAGLANDINS USEFUL AS MEDICAMENTS THE PROCTER & GAMBLE COMPANY (US) 1999-10-07 WO disclosed
WO-1999012896-A1 AROMATIC C16-C20-SUBSTITUTED TETRAHYDRO PROSTAGLANDINS USEFUL AS FP AGONISTS THE PROCTER & GAMBLE COMPANY (US) 1999-03-18 WO disclosed
EP-0723442-A4 LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS CELL PATHWAYS INC (US) 1997-06-11 EP disclosed
EP-0723442-A1 LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS CELL PATHWAYS, INC. (US) 1996-07-31 EP disclosed
WO-1996003987-A1 LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS CELL PATHWAYS, INC. (US) 1996-02-15 WO disclosed