Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796178 | 0.82 | HRH3 (0.68) | HRH2HRH1HRH3ALDH1A1KDM4E | |
| SCHEMBL424774 | 0.82 | HRH3 (0.79) | HRH2HRH1HRH3ALDH1A1KDM4E | |
| SCHEMBL781198 | 0.80 | CHRNB2 (0.59) | HRH3ALDH1A1KDM4ELTA4HESR1 | |
| SCHEMBL29658837 | 0.80 | CHRNB2 (0.59) | HRH3ALDH1A1KDM4ELTA4HESR1 | |
| SCHEMBL30357733 | 0.77 | LTA4H (0.61) | HRH2HRH1HRH3ALDH1A1KDM4E | |
| SCHEMBL7291468 | 0.75 | HRH3 (0.92) | HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL1730425 | 0.75 | LTA4H (0.55) | HRH2HRH1HRH3ALDH1A1HTT | |
| SCHEMBL5228904 | 0.75 | KDM4E (0.58) | HRH2HRH1HRH3ALDH1A1KDM4E | |
| SCHEMBL8795398 | 0.74 | HRH3 (0.84) | HRH2HRH1HRH3ALDH1A1KDM4E | |
| SCHEMBL27866763 | 0.74 | ESR1 (0.54) | HRH3ALDH1A1KDM4ESMN1; SMN2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |