Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.68 |
| ▸ | HRH1 | P35367 | 3/20 | 0.68 |
| ▸ | HRH2 | P25021 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CCR3 | P51677 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | SCN1A | P35498 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291468 | 0.85 | HRH3 (0.92) | HRH3HRH1HRH2ALDH1A1MAPK1 | |
| SCHEMBL491737 | 0.83 | HRH3 (0.72) | HRH3HRH1HRH2ALDH1A1KDM4E | |
| SCHEMBL6444331 | 0.82 | HRH2 (0.56) | HRH3HRH1HRH2ALDH1A1KDM4E | |
| SCHEMBL5858633 | 0.82 | HRH3 (0.71) | HRH3HRH1HRH2ALDH1A1KDM4E | |
| SCHEMBL7006505 | 0.81 | MAPK1 (0.73) | HRH3HRH1ALDH1A1KDM4EHTT | |
| SCHEMBL14714916 | 0.81 | HRH3 (1.00) | HRH3HRH1HRH2ALDH1A1KDM4E | |
| SCHEMBL1728618 | 0.81 | HRH1 (0.58) | HRH3HRH1HRH2ALDH1A1HTT | |
| SCHEMBL30357733 | 0.81 | LTA4H (0.61) | HRH3HRH1HRH2ALDH1A1KDM4E | |
| SCHEMBL8795398 | 0.81 | HRH3 (0.84) | HRH3HRH1HRH2ALDH1A1KDM4E | |
| SCHEMBL2230279 | 0.80 | ALDH1A1 (0.65) | HRH3ALDH1A1KDM4EHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103304491-A | Preparation method of gefitinib | LIANYUNGANG SHENGHE BIOTECHNOLOGY CO LTD | 2013-09-18 | — | — | CN | claimed |
| CN-103304491-A | Preparation method of gefitinib | LIANYUNGANG SHENGHE BIOTECHNOLOGY CO LTD | 2013-09-18 | — | — | CN | disclosed |
| CN-100429204-C | Process for preparing 4- (3 '-chloro-4' -fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | CN | disclosed |
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |