Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 16/20 | 0.42 |
| ▸ | CTSK | P43235 | 14/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447568 | 0.88 | CTSS (0.54) | CTSSCTSKCTSLCTSB | |
| SCHEMBL6447806 | 0.87 | PDE4A (0.32) | — | |
| SCHEMBL6443401 | 0.83 | ZDHHC20 (0.30) | — | |
| SCHEMBL6442263 | 0.81 | SMN1; SMN2 (0.35) | CTSSCTSKCTSLCTSB | |
| SCHEMBL6443436 | 0.79 | ACHE (0.40) | — | |
| SCHEMBL6447225 | 0.79 | CTSS (0.44) | CTSSCTSKCTSLCTSBMEN1 | |
| SCHEMBL1304101 | 0.79 | TDP1 (0.53) | CTSSCTSKCTSLCTSBMEN1 | |
| SCHEMBL6443446 | 0.77 | HRH4 (0.31) | — | |
| SCHEMBL6446210 | 0.77 | ACHE (0.45) | — | |
| SCHEMBL6822169 | 0.76 | ZDHHC20 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |