Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448931 | 0.89 | PTGER3 (0.46) | PTGER3KDM4ESMN1; SMN2NPC1PKM | |
| SCHEMBL6448941 | 0.89 | CSNK2A2 (0.46) | PTGER3KDM4ESMN1; SMN2NPC1PKM | |
| SCHEMBL6324529 | 0.83 | MAPT (0.52) | MAPK1KDM4ESMN1; SMN2NPC1PKM | |
| SCHEMBL6448237 | 0.82 | STK39 (0.49) | PTGER3SMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL6447207 | 0.82 | WNT3A (0.46) | PTGER3KDM4ESMN1; SMN2NPC1PKM | |
| SCHEMBL6446020 | 0.81 | KMT2A (0.48) | PTGER3KDM4EL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL6445732 | 0.81 | TSHR (0.48) | MAPK1KDM4ESMN1; SMN2NPC1PKM | |
| SCHEMBL6445774 | 0.80 | PTGER3 (0.54) | PTGER3KDM4ESMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6447124 | 0.80 | PTGER3 (0.52) | PTGER3KDM4ESMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6445474 | 0.80 | KDM4E (0.53) | MAPK1PTGER3KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | BRISTOL-MYERS SQUIBB COMPANY | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | MAPK1 470/4885PTGER3 332/4885KDM4E 4375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.