Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444549 | 0.93 | NPC1 (0.46) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 | |
| SCHEMBL6447202 | 0.92 | KMT2A (0.46) | NPC1RAB9AKDM4ESMN1; SMN2ABL1 | |
| SCHEMBL6445978 | 0.91 | SNCA (0.47) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 | |
| SCHEMBL6447053 | 0.90 | CSNK2A2 (0.49) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 | |
| SCHEMBL6445760 | 0.90 | CSNK2A2 (0.52) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 | |
| SCHEMBL6445844 | 0.90 | ABL1 (0.48) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 | |
| SCHEMBL6444242 | 0.89 | RAB9A (0.52) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6445816 | 0.89 | BCAT2 (0.49) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 | |
| SCHEMBL6446020 | 0.89 | KMT2A (0.48) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 | |
| SCHEMBL6449332 | 0.89 | NPC1 (0.47) | NPC1RAB9AKDM4ESMN1; SMN2CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | BRISTOL-MYERS SQUIBB COMPANY | 2005-06-30 | — | — | US | claimed |
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | BRISTOL-MYERS SQUIBB COMPANY | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | NPC1 1404/4885RAB9A 1792/4885KDM4E 4375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.