Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ECE1 | P42892 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CTRC | Q99895 | 1/20 | 0.50 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6452567 | 0.98 | CA2 (0.56) | LMNAECE1CA2CTRCGPR132 | |
| SCHEMBL7279498 | 0.92 | CTSD (0.60) | LMNAECE1CA2GPR132CYP3A4 | |
| SCHEMBL7277346 | 0.88 | CA2 (0.56) | CA2BACE1CTSD | |
| SCHEMBL6444614 | 0.85 | ECE1 (0.67) | LMNAECE1CTRCGPR132CYP3A4 | |
| SCHEMBL7270440 | 0.83 | ALDH1A1 (0.54) | LMNACA2BACE1CTSDKMT2A | |
| SCHEMBL7269055 | 0.83 | CA2 (0.52) | LMNACA2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7270066 | 0.83 | CA2 (0.56) | LMNAECE1CA2CYP3A4CYP2C9 | |
| SCHEMBL7268971 | 0.82 | CTSD (0.63) | CA2CYP3A4CYP2C19CTSD | |
| SCHEMBL7332956 | 0.82 | CTSD (0.51) | CA2BACE1CTSDRAB9A | |
| SCHEMBL7275770 | 0.81 | CTSD (0.65) | CA2CYP3A4CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |