Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554008 | 0.86 | SLC6A3 (0.48) | CYP2D6CHRM2CHRM1SLC6A2SLC6A3 | |
| SCHEMBL6447344 | 0.86 | SLC6A3 (0.48) | CYP2D6CHRM2CHRM1SLC6A2SLC6A3 | |
| SCHEMBL5549391 | 0.84 | CYP2D6 (0.39) | CYP2D6MBTD1L3MBTL3OPRM1CHRM2 | |
| SCHEMBL5549400 | 0.80 | CYP2D6 (0.47) | CYP2D6MBTD1L3MBTL3OPRM1CHRM2 | |
| SCHEMBL5553082 | 0.80 | CYP2D6 (0.47) | CYP2D6MBTD1L3MBTL3OPRM1CHRM2 | |
| SCHEMBL5555138 | 0.80 | CYP2D6 (0.43) | CYP2D6CHRM2CHRM1LTA4HSLC6A2 | |
| SCHEMBL5555115 | 0.76 | CYP2D6 (0.40) | CYP2D6MBTD1L3MBTL3OPRM1CHRM2 | |
| SCHEMBL3041069 | 0.75 | CYP2D6 (0.52) | CYP2D6MBTD1L3MBTL3OPRM1CHRM2 | |
| SCHEMBL16982012 | 0.74 | CYP2D6 (0.56) | CYP2D6OPRM1CHRM2CHRM1LTA4H | |
| SCHEMBL5553102 | 0.74 | BMPR1B (0.42) | CYP2D6CHRM2CHRM1LTA4HMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245543-A1 | Histamine-3 receptor antagonists | PFIZER INC | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245543-A1 | Histamine-3 receptor antagonists | HRH3, HRH4, HRH2 | CYP2D6 941/4885MBTD1 3182/4885L3MBTL3 2771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.