Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.48 |
| ▸ | AHR | P35869 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554008 | 1.00 | SLC6A3 (0.48) | SLC6A3SLC6A2SLC6A4AHRCYP2D6 | |
| SCHEMBL31669101 | 0.88 | SLC6A3 (0.55) | SLC6A3SLC6A2SLC6A4CYP2D6MEN1 | |
| SCHEMBL22206745 | 0.86 | SLC6A3 (0.56) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL22206766 | 0.86 | SLC6A3 (0.56) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL29585835 | 0.86 | SLC6A3 (0.56) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL29585404 | 0.86 | SLC6A3 (0.56) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL6447211 | 0.86 | CYP2D6 (0.40) | SLC6A3SLC6A2SLC6A4CYP2D6CHRM2 | |
| SCHEMBL11626449 | 0.86 | SLC6A2 (0.51) | SLC6A3SLC6A2SLC6A4AHRCYP2D6 | |
| SCHEMBL5555138 | 0.83 | CYP2D6 (0.43) | SLC6A3SLC6A2SLC6A4CYP2D6ALDH1A1 | |
| SCHEMBL11623680 | 0.81 | OGA (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245543-A1 | Histamine-3 receptor antagonists | PFIZER INC | 2005-11-03 | — | — | US | claimed |
| US-20050245543-A1 | Histamine-3 receptor antagonists | PFIZER INC | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245543-A1 | Histamine-3 receptor antagonists | HRH3, HRH4, HRH2 | SLC6A3 22/4885SLC6A2 53/4885SLC6A4 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.