Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.49 |
| ▸ | MAT2A | P31153 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10818689 | 0.71 | CYP1A2 (0.54) | MAT2ACYP1A2PDE10AMAPK1HTT | |
| SCHEMBL762447 | 0.69 | MAPK1 (0.66) | CYP1A2PDE10AALDH1A1MAPK1HTT | |
| SCHEMBL7814352 | 0.69 | HCAR1 (0.34) | DCTPP1MAT2ACYP1A2PDE10AP2RX7 | |
| SCHEMBL25112562 | 0.68 | PDE10A (0.63) | PDE10AALDH1A1 | |
| SCHEMBL10818437 | 0.68 | PDE10A (0.56) | CYP1A2PDE10AALDH1A1MAPK1HTT | |
| SCHEMBL1318443 | 0.68 | MAPK8 (0.50) | MAT2ACYP1A2ALDH1A1MAPK1HTT | |
| SCHEMBL3441050 | 0.67 | PI4KA (0.49) | MAT2AMAPK1POLB | |
| SCHEMBL23912375 | 0.66 | PIK3CD (0.48) | MAT2AALDH1A1SMN1; SMN2POLBRECQL | |
| SCHEMBL23105555 | 0.66 | L3MBTL1 (0.45) | CYP1A2PDE10AMAPK1SMN1; SMN2NR1H2 | |
| SCHEMBL17671374 | 0.66 | DCTPP1 (1.00) | DCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |