Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813650 | 0.78 | CYP11B2 (0.31) | — | |
| SCHEMBL7817046 | 0.71 | POLB (0.33) | CYP1A2ALDH1A1 | |
| SCHEMBL6447298 | 0.69 | DCTPP1 (0.49) | PDE10ACYP1A2MAT2ADCTPP1ALDH1A1 | |
| SCHEMBL10815729 | 0.66 | PPARG (0.47) | HCAR1PDE10ACYP1A2PI4KAPI4K2B | |
| SCHEMBL10818689 | 0.63 | CYP1A2 (0.54) | PDE10ACYP1A2MAT2ASMN1; SMN2 | |
| SCHEMBL23105555 | 0.63 | L3MBTL1 (0.45) | PDE10ACYP1A2SMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL25112562 | 0.63 | PDE10A (0.63) | PDE10AALDH1A1 | |
| SCHEMBL10817241 | 0.62 | PPARG (0.48) | HCAR1PDE10ACYP1A2PI4KAPI4K2B | |
| SCHEMBL10817583 | 0.61 | PDE10A (0.56) | HCAR1PDE10ACYP1A2MAT2APPARG | |
| SCHEMBL1623493 | 0.61 | PPARG (0.39) | NR1H2NR1H3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091941-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-18 | — | — | EP | claimed |
| WO-2000001675-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-13 | — | — | WO | claimed |
| EP-1091941-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001675-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-13 | — | — | WO | disclosed |