SCHEMBL6447484

SCHEMBL6447484

CC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Zr](Cl)(Cl)(C1C(C)=Cc2c(-c3cccc4ccccc34)cccc21)[SiH](C)[Si](C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 1/20 0.34
ENPP1 P22413 1/20 0.34
NPC1 O15118 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALOX15 P16050 3/20 0.31
DHFR P00374 1/20 0.30
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6446037 0.89 MAPT (0.33) ENPP3ENPP1NPC1MAPTRAB9A
SCHEMBL137885 0.88 ENPP3 (0.32) ENPP3ENPP1NPC1MAPTRAB9A
SCHEMBL5836075 0.85 KDM4E (0.32)
SCHEMBL6451919 0.84
SCHEMBL5837290 0.84
SCHEMBL273550 0.81 NPC1 (0.31) NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL3401090 0.81
SCHEMBL8681252 0.81
SCHEMBL139428 0.80 DHFR (0.34) ENPP3ENPP1MAPTDHFRMAOA
SCHEMBL8677996 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6841634-B1 Modified supported catalysts for the polymerization of olefins BOREALIS TECHNOLOGY OY (FI) 2005-01-11 US disclosed
US-6664352-B1 Impregnating porous particulate support in mechanically fluidized state with catalyst material in mixer having horizontal axis counter-rotating interlocking mixing paddles BOREALIS TECHNOLOGY OY (FI) 2003-12-16 US disclosed
US-20030078340-A1 Impregnating a mechanically fluidized porous particulate support material with a catalyst and polymerizing monomer(s) to produce polymer; heating mixture antioxidants, ultraviolet radiation stabilizer, diluent and metal stearate; depositing BOREALIS TECHNOLOGY OY (FI) 2003-04-24 US disclosed
US-5945367-A Metallocenes with silyl-substituted bridges and their use for olefin polymerization BOREALIS AG (AT) 1999-08-31 US disclosed