Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.42 |
| ▸ | CTSL | P07711 | 10/20 | 0.42 |
| ▸ | CTSS | P25774 | 9/20 | 0.42 |
| ▸ | CTSB | P07858 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448205 | 0.91 | CTSL (0.47) | CTSKCTSLCTSSCTSB | |
| SCHEMBL6443534 | 0.91 | HDAC6 (0.37) | CTSKCTSLCTSSHDAC1HDAC6 | |
| SCHEMBL6446814 | 0.90 | CTSL (0.41) | CTSKCTSLCTSSCTSB | |
| SCHEMBL6446486 | 0.86 | CTSK (0.41) | CTSKCTSLCTSSCTSBHDAC6 | |
| SCHEMBL6021296 | 0.82 | CTSL (0.38) | CTSKCTSLCTSSCTSBHDAC1 | |
| SCHEMBL6021888 | 0.82 | CTSK (0.44) | CTSKCTSLCTSSCTSBHDAC1 | |
| SCHEMBL6444782 | 0.81 | CTSK (0.53) | CTSKCTSLCTSSCTSB | |
| SCHEMBL6446480 | 0.81 | GUSB (0.36) | CTSKCTSLCTSSCTSBHDAC6 | |
| SCHEMBL6443383 | 0.81 | CTSS (0.51) | CTSKCTSLCTSSCTSB | |
| SCHEMBL6821937 | 0.80 | CTSK (0.43) | CTSKCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |