Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.48 |
| ▸ | LAP3 | P28838 | 3/20 | 0.47 |
| ▸ | GRN | P28799 | 1/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448243 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL6447013 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL6447009 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL15623775 | 0.89 | ALDH1A1 (0.62) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL4027352 | 0.87 | PLA2G2A (0.61) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL14637109 | 0.84 | PLA2G2A (0.62) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL26644327 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL15680095 | 0.84 | FOLH1 (0.60) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL4572547 | 0.84 | FOLH1 (0.60) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL5092487 | 0.83 | ALDH1A1 (0.59) | ALDH1A1MEN1LMNAKMT2AFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130941-A1 | Methods of treating alzheimer's disease | PHARMACIA & UPJOHN COMPANY LLC | 2005-06-16 | — | — | US | disclosed |
| US-5753652-A | Antiretroviral hydrazine derivatives | NOVARTIS CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0521827-B1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA GEIGY AG (CH) | 1996-09-25 | — | — | EP | disclosed |
| EP-0521827-A1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130941-A1 | Methods of treating alzheimer's disease | BACE1, PSEN1, BACE2 | ALDH1A1 889/4885MEN1 2134/4885LMNA 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.