Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030532 | 0.90 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL8339674 | 0.86 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL5843980 | 0.78 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL5600147 | 0.78 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL5875479 | 0.75 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL5843102 | 0.75 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL6094145 | 0.74 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL5843479 | 0.74 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL16606729 | 0.74 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5843501 | 0.73 | CRHR1 (0.59) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209250-A1 | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | PFIZER INC | 2005-09-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209250-A1 | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | CRH, MC2R, CRHR2 | CRHR1 5/4885NR4A2 1262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.