Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5600415 | 0.81 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6448260 | 0.81 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5599644 | 0.77 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL5600343 | 0.75 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7615962 | 0.75 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL7445210 | 0.75 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL5599796 | 0.74 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5600393 | 0.73 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5599438 | 0.73 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5600317 | 0.72 | CRHR1 (0.44) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209250-A1 | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | PFIZER INC | 2005-09-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209250-A1 | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | CRH, MC2R, CRHR2 | CRHR1 5/4885L3MBTL1 3511/4885THRB 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.