Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599533 | 0.82 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6448575 | 0.81 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL6303429 | 0.79 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6303231 | 0.78 | CRHR1 (0.78) | CRHR1 | |
| SCHEMBL7621981 | 0.76 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7432507 | 0.76 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6310549 | 0.75 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL6448333 | 0.75 | TLR8 (0.33) | CRHR1 | |
| SCHEMBL6053095 | 0.74 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6053105 | 0.74 | CRHR1 (0.47) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209250-A1 | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | PFIZER INC | 2005-09-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209250-A1 | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists | CRH, MC2R, CRHR2 | CRHR1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.