Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794940 | 0.78 | SIRT2 (0.49) | CHRM2CHRM4CHRM1CHRM3SIRT2 | |
| SCHEMBL25263647 | 0.76 | SLC6A1 (0.46) | ALDH1A1TSHRL3MBTL1LTA4H | |
| SCHEMBL25387022 | 0.76 | SLC6A1 (0.46) | ALDH1A1TSHRL3MBTL1LTA4H | |
| SCHEMBL25309637 | 0.76 | SLC6A1 (0.46) | ALDH1A1TSHRL3MBTL1LTA4H | |
| SCHEMBL7181950 | 0.76 | ACKR3 (0.45) | CHRM2CHRM4CHRM1CHRM3SIGMAR1 | |
| SCHEMBL7258203 | 0.75 | SIRT2 (0.43) | SIGMAR1SIRT2 | |
| SCHEMBL14993551 | 0.75 | SIRT2 (0.49) | CHRM2CHRM4CHRM1CHRM3SIRT2 | |
| SCHEMBL4382643 | 0.75 | SIRT2 (0.54) | SIRT2 | |
| SCHEMBL8125239 | 0.75 | SIRT2 (0.49) | CHRM2CHRM4CHRM1CHRM3SIRT2 | |
| SCHEMBL1041048 | 0.75 | SIRT2 (0.49) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |