Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL947677 | 0.85 | KDM4E (0.49) | GPR119 | |
| SCHEMBL14433203 | 0.80 | GPR119 (0.46) | GPR119 | |
| SCHEMBL4301302 | 0.80 | TACR1 (0.42) | CKS1BSKP1SKP2GPR119 | |
| SCHEMBL7719017 | 0.78 | USP30 (0.51) | GPR119 | |
| SCHEMBL7719020 | 0.78 | USP30 (0.51) | GPR119 | |
| SCHEMBL3954399 | 0.78 | THRB (0.58) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL1448716 | 0.76 | TACR1 (0.41) | CKS1BSKP1SKP2 | |
| SCHEMBL1448717 | 0.76 | LMNA (0.41) | — | |
| SCHEMBL3712707 | 0.76 | MEN1 (0.59) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6617534 | 0.76 | MAPK1 (0.40) | CHRM2CHRM4CHRM1CHRM3CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |