Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.63 |
| ▸ | HTR2A | P28223 | 11/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.63 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056360 | 0.81 | SLC6A4 (0.75) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL18646614 | 0.79 | HSPB1 (0.58) | SLC6A4HTR2AKCNH2KDM4EMEN1 | |
| SCHEMBL5837192 | 0.78 | SLC6A4 (1.00) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL6056329 | 0.77 | SLC6A4 (0.85) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL641262 | 0.76 | MAPT (0.71) | SLC6A4HTR2AKCNH2CACNA1CKDM4E | |
| SCHEMBL44109 | 0.75 | TAAR1 (0.68) | SLC6A4ADRA1ATAAR1SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL34462923 | 0.74 | TAAR1 (0.66) | SLC6A4ADRA1ATAAR1SLC6A2SLC6A3 | |
| SCHEMBL5836497 | 0.73 | HTR2A (0.68) | SLC6A4HTR2AKCNH2SOS1CYP2D6 | |
| SCHEMBL5837537 | 0.72 | HTR2A (0.65) | SLC6A4HTR2AKCNH2CACNA1CKDM4E | |
| SCHEMBL441642 | 0.72 | TAAR1 (0.54) | HTR2ATAAR1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059654-A1 | Method for treatment of depression and anxiety disorders by combination therapy | ARNERIC STEPHEN P (US) | 2005-03-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059654-A1 | Method for treatment of depression and anxiety disorders by combination therapy | SLC6A2, SLC18A2, ADRA2C | SLC6A4 4/4885HTR2A 16/4885KCNH2 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.