Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463130 | 0.89 | POLB (0.51) | POLBALDH1A1HTR7HTR1A | |
| SCHEMBL6457124 | 0.89 | ADRA1D (0.50) | POLBHTR7HTR1A | |
| SCHEMBL6462987 | 0.87 | HTR7 (0.47) | POLBALDH1A1MAPK10HTR7HTR1A | |
| SCHEMBL6466592 | 0.87 | HTR7 (0.55) | POLBMCHR1HTR7HTR1ASLC6A12 | |
| SCHEMBL6461236 | 0.86 | HTR7 (0.46) | POLBHTR7HTR1A | |
| SCHEMBL6472358 | 0.86 | DRD4 (0.56) | POLBMCHR1HTR7HTR1ASLC6A12 | |
| SCHEMBL6451227 | 0.85 | KMT2A (0.48) | POLBHTR7HTR1A | |
| SCHEMBL6458101 | 0.85 | HTR7 (0.54) | POLBMCHR1HTR7HTR1ASLC6A12 | |
| SCHEMBL6462598 | 0.85 | HTR7 (0.54) | POLBMCHR1HTR7HTR1ASLC6A12 | |
| SCHEMBL6467624 | 0.84 | HRH2 (0.55) | POLBHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |