Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HRH2 | P25021 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462987 | 0.92 | HTR7 (0.47) | POLBHTR7HTR1AHRH2HRH1 | |
| SCHEMBL6466592 | 0.92 | HTR7 (0.55) | POLBHTR7HTR1AHRH2HRH1 | |
| SCHEMBL6457124 | 0.92 | ADRA1D (0.50) | POLBHTR7HTR1AHRH2HRH1 | |
| SCHEMBL6461236 | 0.91 | HTR7 (0.46) | POLBHTR7HTR1AHRH2HRH1 | |
| SCHEMBL6462598 | 0.89 | HTR7 (0.54) | POLBHTR7HTR1ASLC6A5HTR2A | |
| SCHEMBL6458101 | 0.89 | HTR7 (0.54) | POLBHTR7HTR1ASLC6A5HTR2A | |
| SCHEMBL6472358 | 0.89 | DRD4 (0.56) | POLBHTR7HTR1ADRD4DRD3 | |
| SCHEMBL6467624 | 0.89 | HRH2 (0.55) | POLBHTR7HTR1AHRH2HRH1 | |
| SCHEMBL6451907 | 0.89 | POLB (0.50) | POLBHTR7HTR1AALDH1A1 | |
| SCHEMBL6457611 | 0.88 | SLC6A5 (0.51) | HTR7HTR1ADRD4SLC6A5HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |
| EP-1012147-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999006387-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-11 | — | — | WO | disclosed |