Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28805026 | 0.76 | XDH (0.55) | MAPTLMNAGAAXDHAPP | |
| SCHEMBL15106737 | 0.75 | PPARA (0.43) | MAPTPOLBALDH1A1HTTMAPK1 | |
| SCHEMBL14637888 | 0.75 | PPARA (0.43) | MAPTPOLBALDH1A1HTTMAPK1 | |
| SCHEMBL15106924 | 0.75 | PPARA (0.43) | MAPTPOLBALDH1A1HTTMAPK1 | |
| SCHEMBL24019055 | 0.73 | USP30 (0.43) | MAPTGAAALOX5ALDH1A1USP30 | |
| SCHEMBL14656404 | 0.72 | MAPT (0.55) | MAPTPOLBLMNAGAAALOX5 | |
| SCHEMBL16755954 | 0.72 | MAPT (0.96) | MAPTPOLBLMNAGAARIPK1 | |
| SCHEMBL3477702 | 0.72 | MAPT (0.96) | MAPTPOLBLMNAGAARIPK1 | |
| SCHEMBL6464643 | 0.72 | RAB9A (0.52) | MAPTPOLBLMNAGAAALOX5 | |
| SCHEMBL1473102 | 0.72 | LMNA (0.58) | MAPTPOLBLMNAGAARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852720-B2 | Thiazol-2-yl-imine compounds as PDE-7 inhibitors | PFIZER INC. (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1492530-A1 | THIAZOL-2-YL-IMINE COMPOUNDS AS PDE-7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082277-A1 | THIAZOL-2-YL-IMINE COMPOUNDS AS PDE-7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-09 | — | — | WO | disclosed |
| US-20030186988-A1 | Thiazol-2-yl-imine compounds as PDE-7 inhibitors | WARNER-LAMBERT COMPANY LLC | 2003-10-02 | — | — | US | disclosed |
| EP-1348433-A1 | Thiazol-2-yl-imine compounds as PDE-7 inhibitors | Warner-Lambert Company LLC (US) | 2003-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186988-A1 | Thiazol-2-yl-imine compounds as PDE-7 inhibitors | PDE7A, PDE3A, PDE9A | MAPT 2508/4885POLB 1348/4885LMNA 3249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.