Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.49 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6456150 | 0.84 | MKNK1 (0.58) | PARP2PARP3MKNK1MKNK2MAP3K5 | |
| SCHEMBL6454967 | 0.79 | MKNK1 (0.49) | PARP2PARP3MKNK1MKNK2MAP3K5 | |
| SCHEMBL4233748 | 0.74 | MKNK1 (0.58) | PARP2MKNK1MKNK2MAP3K5HTR1A | |
| SCHEMBL6446339 | 0.73 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5 | |
| SCHEMBL6451281 | 0.73 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5HRH1TOP2A | |
| SCHEMBL6447864 | 0.72 | MKNK1 (0.46) | PARP2PARP3MKNK1MKNK2MAP3K5 | |
| SCHEMBL6447886 | 0.72 | OPRM1 (0.54) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL16828784 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2MAP3K5TOP2AHSP90AB1 | |
| SCHEMBL6450115 | 0.72 | MAP3K5 (0.47) | PARP2PARP3MKNK1MKNK2MAP3K5 | |
| SCHEMBL5372678 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2MAP3K5HRH1TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964974-B2 | 2,3-oxidosqualene-lanosterol cyclase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-11-15 | — | — | US | disclosed |